Discovering the Option That Fits You Best
A look at Semaglutide w/ Vitamin B12 and Tirzepatide w/ Vitamin B3.
At WellYou Rx, we compound our medications with supportive B-vitamins because your body deserves nutrition that works with treatment—not against it. While Semaglutide and Tirzepatide are powerful and effective on their own, adding targeted B-vitamins helps support the natural metabolic shifts that occur during weight loss.
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These vitamins don’t change the medications themselves—they simply help your body function smoothly as your appetite, digestion, and metabolic pathways adjust.
Semaglutide + B12
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✔ Supports Steady, Gradual Weight Loss
Semaglutide works through a GLP-1 pathway that reduces appetite, increases satiety, and helps regulate blood sugar. The weight loss progression tends to be gentle and consistent.
✔ Helps Regulate Appetite & Cravings
By slowing gastric emptying, semaglutide helps you feel full sooner and stay full longer, reducing overeating and stabilizing hunger signals.
✔ Paired with B12 for Energy & Metabolic Support
Cyanocobalamin supports energy production, healthy nerve function, and normal metabolic processing.
This helps counteract mild fatigue that sometimes occurs as calorie intake shifts.
✔ Typically Milder Early Side Effects
Because semaglutide works through one metabolic pathway, many patients find that dose increases feel smoother and gentler.
✔ Ideal for Patients Wanting a Balanced, Sustainable Pace
Semaglutide is a strong option for those who prefer gradual results and a more measured approach to weight support.
✔ Weekly Dosing for Convenience
A simple, once-weekly injection fits into most lifestyles without disruption.
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Tirzepatide + B3
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✔ Supports Faster & More Significant Weight Loss
Tirzepatide acts on both GLP-1 and GIP receptors, often resulting in more accelerated and visible progress for many patients.
✔ Stronger Appetite Suppression
The dual-pathway effect enhances satiety and reduces hunger signals more robustly than GLP-1 alone, which can lead to quicker behavioral change.
✔ Paired with B3 for Cellular Energy Balance
Nicotinamide (a form of Vitamin B3) supports NAD+ pathways involved in energy production.
This helps your cells function efficiently as your metabolism adjusts to a more intensive treatment.
✔ Helps Support Glucose Control & Metabolic Efficiency
B3 contributes to stable glucose utilization and cellular metabolic health — making it a complementary match for tirzepatide’s mechanism.
✔ May Deliver Quicker Momentum for Motivation
Patients wanting more rapid progress often find tirzepatide gives them an earlier sense of change, which can help reinforce lifestyle shifts.
✔ Weekly Dosing for Simplicity
Despite its dual action, dosing remains once per week for ease of use.
